Author

Yuting Cousineau

Montreal Neurological Institute and Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:electronic health records· 1 Organism:mouse· 1

Frequent Co-Authors

Austen J. MilnerwoodiD· 3 shared Anouar KhayachiiD· 2 shared Anusha KameshiD· 2 shared Agostinho SantosiD· 1 shared Alessia PietrantonioiD· 1 shared Alla TimofeevaiD· 1 shared Andrea PietrantonioiD· 1 shared Anton EmelyanoviD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Austen J. MilnerwoodORCID

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Author profile →

3 papers

Recent·Most cited

Emergent glutamate & dopamine dysfunction in VPS35(D620N) knock-in mice and rapid reversal by LRRK2 inhibition

Anusha Kamesh, Chelsie Kadgien, Naila Kuhlmann, S. Coady, Andrea Pietrantonio, Yuting Cousineau, Anouar Khayachi, Agostinho Santos, Emily P. Hurley, Jessica C. Barron, Matthew P. Parsons, Austen J. Milnerwood

This study shows that VPS35(D620N) mutation leads to increased glutamate and dopamine transmission in mice, which can be reversed by LRRK2 inhibition.

npj Parkinson s Disease · May 3, 2025Peer-reviewedNeuroscience

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

Jace Jones-Tabah, Kathy He, Nathan C. Karpilovsky, Konstantin A. Senkevich, Ghislaine Deyab, Isabella Pietrantonio, Thomas Goiran, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther del Cid‐Pellitero, Carol X.‐Q. Chen, Wen Luo, Zhipeng You, Narges Abdian, , Edward A. Fon

This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.

Molecular Neurodegeneration · Nov 24, 2024Peer-reviewedNeuroscience

Molecular signatures of hyperexcitability and lithium responsiveness in bipolar disorder patient neurons provide alternative therapeutic strategies.

Anouar Khayachi, Malak Abuzgaya, Yumin Liu, Chuan Jiao, Kurt Dejgaard, Lenka Schorova, Anusha Kamesh, Qin He, Yuting Cousineau, Alessia Pietrantonio, Nargess Farhangdoost, Charles-Etienne Castonguay, Boris Chaumette, Martin Alda, Guy Armand Rouleau, Austen J. Milnerwood

The paper identifies molecular signatures of neuronal hyperexcitability and lithium responsiveness in bipolar disorder neurons, suggesting new therapeutic strategies targeting Akt and AMPK pathways.

EBioMedicine · May 20, 2024Peer-reviewedNeuroscience