CRISPR/Cas9-engineered inducible gametocyte producer lines as a novel tool for basic and applied research on Plasmodium falciparum malaria transmission stages
S. D. Boltryk, A. Passecker, A. Alder, M. van de Vegte-Bolmer, R. W. Sauerwein, N. M. B. Brancucci, H.-P. Beck, T.-W. Gilberger, T. S. Voss
This paper develops CRISPR/Cas9-engineered inducible gametocyte producer lines for mass production of P. falciparum gametocytes, achieving 75% sexual commitment and enabling genetic studies of transmission stages.
bioRxiv · Oct 5, 2020 · PreprintMicrobiology