R. W. Sauerwein

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

Novel functional insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies

This paper identifies sporozoite-specific and enriched proteins in Plasmodium falciparum by integrating 26 transcriptomic and proteomic studies, revealing key pathways and potential vaccine targets.

CRISPR/Cas9-engineered inducible gametocyte producer lines as a novel tool for basic and applied research on Plasmodium falciparum malaria transmission stages

This paper develops CRISPR/Cas9-engineered inducible gametocyte producer lines for mass production of P. falciparum gametocytes, achieving 75% sexual commitment and enabling genetic studies of transmission stages.

Zonal human hepatocytes are differentially permissive to Plasmodium falciparum malaria parasites

The paper shows that Plasmodium falciparum preferentially infects zone 3 hepatocytes expressing glutamine synthetase, highlighting metabolic differences in liver cell subtypes.