T. S. Voss

Expression of the MSPDBL2 antigen in a discrete subset of Plasmodium falciparum schizonts is regulated by GDV1 but not linked to sexual commitment

Variation in Plasmodium falciparum sexual commitment rates and responses to environmental modification

This study measures sexual commitment rates in Plasmodium falciparum using two methods, finds higher sensitivity with an early marker, and reports variation across isolates and lab lines.

Revisiting the effect of pharmaceuticals on transmission stage formation in the malaria parasite Plasmodium falciparum

This study investigates how antimalarial drugs affect gametocyte formation in Plasmodium falciparum, finding that drug-induced effects on sexual commitment are only observed at concentrations that inhibit parasite survival.

The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites

This study identifies PfPDK1 as an essential upstream activator of PfPKAc in malaria parasites, crucial for parasite survival and a potential drug target.

Investigation of heterochromatin protein 1 function in the malaria parasite Plasmodium falciparum using a conditional domain deletion and swapping approach

This study investigates PfHP1 domains in Plasmodium falciparum using CRISPR/Cas9 and DiCre/LoxP, showing their roles in nuclear targeting, heterochromatin formation, and parasite proliferation.

The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum

The paper identifies PfAP2-HC as a heterochromatin component in Plasmodium falciparum, showing it binds heterochromatin without DNA-binding and is dependent on heterochromatin protein 1.

GDV1 C-terminal truncation of 39 amino acids disrupts sexual commitment in Plasmodium falciparum

This study identifies a C-terminal truncation mutation in GDV1 that disrupts sexual commitment in Plasmodium falciparum by destabilizing the protein, despite normal nuclear import and HP1 interaction.

CRISPR/Cas9-engineered inducible gametocyte producer lines as a novel tool for basic and applied research on Plasmodium falciparum malaria transmission stages

This paper develops CRISPR/Cas9-engineered inducible gametocyte producer lines for mass production of P. falciparum gametocytes, achieving 75% sexual commitment and enabling genetic studies of transmission stages.

Composition and stage dynamics of mitochondrial complexes in Plasmodium falciparum

This study uses complexome profiling to analyze mitochondrial protein complexes in Plasmodium falciparum across different life stages, revealing stage-specific composition and functional shifts.