Author

A. Passecker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:plant (other)· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

N. M. B. Brancucci· 4 shared T. S. Voss· 4 shared E. Hitz· 2 shared A. Alder· 1 shared B. T. Thommen· 1 shared H. T. N. Bui· 1 shared H.-P. Beck· 1 shared I. Vakonakis· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

N. M. B. Brancucci

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4 papers

Recent·Most cited

Revisiting the effect of pharmaceuticals on transmission stage formation in the malaria parasite Plasmodium falciparum

B. T. Thommen, A. Passecker, T. Buser, E. Hitz, T. S. Voss, N. M. B. Brancucci

This study investigates how antimalarial drugs affect gametocyte formation in Plasmodium falciparum, finding that drug-induced effects on sexual commitment are only observed at concentrations that inhibit parasite survival.

bioRxiv · Nov 18, 2021Cell Biology

The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites

E. Hitz, N. Wiedemar, A. Passecker, N. M. B. Brancucci, I. Vakonakis, P. Maeser, T. S. Voss

This study identifies PfPDK1 as an essential upstream activator of PfPKAc in malaria parasites, crucial for parasite survival and a potential drug target.

bioRxiv · May 27, 2021Microbiology

Investigation of heterochromatin protein 1 function in the malaria parasite Plasmodium falciparum using a conditional domain deletion and swapping approach

H. T. N. Bui, A. Passecker, N. M. B. Brancucci, T. S. Voss

This study investigates PfHP1 domains in Plasmodium falciparum using CRISPR/Cas9 and DiCre/LoxP, showing their roles in nuclear targeting, heterochromatin formation, and parasite proliferation.

bioRxiv · Nov 26, 2020Microbiology

CRISPR/Cas9-engineered inducible gametocyte producer lines as a novel tool for basic and applied research on Plasmodium falciparum malaria transmission stages

S. D. Boltryk, A. Passecker, A. Alder, M. van de Vegte-Bolmer, R. W. Sauerwein, N. M. B. Brancucci, H.-P. Beck, T.-W. Gilberger, T. S. Voss

This paper develops CRISPR/Cas9-engineered inducible gametocyte producer lines for mass production of P. falciparum gametocytes, achieving 75% sexual commitment and enabling genetic studies of transmission stages.

bioRxiv · Oct 5, 2020 · PreprintMicrobiology