S. D. Emr

A role for Vps13-mediated lipid transfer at the ER-endosome contact site in ESCRT-mediated sorting

The paper identifies Vps13-mediated lipid transfer at ER-endosome contact sites as essential for ESCRT-mediated sorting during MVB formation.

Adaptor linked K63 di-Ubiquitin activates Nedd4/Rsp5 E3 ligase

The paper shows that Art1, Art4, and Art5 undergo K63-linked di-ubiquitination by Rsp5, enhancing PM recruitment and cargo ubiquitination, while HECT domain exosite protects this modification from cleavage by Ubp2.

Recruitment and organization of ESCRT-0 and ubiquitinated cargo via condensation

The paper investigates how ESCRT-0 and ubiquitinated cargo are recruited and organized via condensation at yeast vacuoles, showing multivalent interactions drive substrate recognition.

A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling

The paper identifies a novel endosomal recycling pathway in yeast and humans involving Mvp1/SNX8 and Vps1, distinct from retromer and Snx4 pathways.

The Hob proteins are novel and conserved lipid binding proteins at ER-PM contact site

This study identifies Hobbit/Hob proteins as conserved lipid-binding proteins at ER-PM contact sites, essential for viability in higher animals.

The yeast Art1 arrestin domain contains disordered insertions that regulate its localization and activity

The paper identifies loop insertions in the yeast Art1 protein that regulate its localization and activity through phosphorylation and cargo specificity.