Author

S. D. Tyrkalska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:zebrafish· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

V. Mulero· 4 shared A. Martinez-Lopez· 3 shared S. Candel· 3 shared A. B. Arroyo· 2 shared A. Pedoto· 2 shared D. Garcia-Moreno· 2 shared M. L. Cayuela· 2 shared P. Mesa-del-Castillo· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersImmunology

V. Mulero

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Author profile →

4 papers

Recent·Most cited

Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammation

A. B. Arroyo, S. D. Tyrkalska, E. Bastida-Martinez, A. J. Monera-Girona, J. Canton-Sandoval, M. Bernal-Carrion, D. Garcia-Moreno, M. Elias-Arnanz, V. Mulero

This study shows that Peds1 deficiency in zebrafish causes myeloid cell apoptosis and worsened inflammation, with plasmalogen supplementation improving outcomes.

bioRxiv · Sep 26, 2023Immunology

A zebrafish model of COVID-19-associated cytokine storm syndrome reveals that the Spike protein signals via TLR2

S. D. Tyrkalska, A. Martinez-Lopez, A. Pedoto, S. Candel, M. L. Cayuela, V. Mulero

This study shows that the S1 domain of SARS-CoV-2 Spike protein induces hyperinflammation in zebrafish larvae via Tlr2/Myd88 signaling, independent of IL-1β, and also triggers emergency myelopoiesis through a Tlr2/Myd88-independent pathway.

bioRxiv · Jul 14, 2022 · PreprintImmunology

Combination therapy targeting inflammasome and fibrogenesis alleviates inflammation and fibrosis in a zebrafish model of silicosis

S. D. Tyrkalska, A. Pedoto, A. Martinez-Lopez, S. Candel, J. A. Ros-Lucas, P. Mesa-del-Castillo, V. Mulero

This study uses a zebrafish model of silicosis to show that combining an inflammasome inhibitor and antifibrotic agent reduces inflammation and fibrosis.

bioRxiv · May 4, 2022 · PreprintImmunology

A zebrafish model of COVID-19-associated cytokine storm syndrome reveals differential proinflammatory activities of Spike proteins of SARS-CoV-2 variants of concern.

S. D. Tyrkalska, A. Martinez-Lopez, A. B. Arroyo, F. J. Martinez-Morcillo, S. Candel, P. Mesa-del-Castillo, D. Garcia-Moreno, M. L. Cayuela, V. Mulero

This paper uses a zebrafish model to study the proinflammatory effects of SARS-CoV-2 Spike proteins from different variants, finding differential inflammatory responses and potential therapeutic targets.

bioRxiv · Dec 5, 2021 · PreprintImmunology