B. Ladoux

A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge

This paper develops a minimal physical model to explain curvotaxis by simulating curved protein complexes at the cell's leading edge and shows it matches experimental observations on curved substrates.

Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

Deposited footprints let cells switch between confined, oscillatory, and exploratory migration

The paper models how cell footprints influence migration patterns, showing cells can switch between confined, oscillatory, and exploratory motion based on footprint deposition and response.

Polarization and motility of one-dimensional multi-cellular trains

The paper models one-dimensional multi-cellular migration, showing that cell-cell interactions lead to multiple motility modes and that MDCK cells operate near a balance between Contact Inhibition of Locomotion and Cryptic Lamellipodia.

Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density

This study investigates how cell adhesion and density influence the hexanematic crossover in epithelial monolayers, showing its dependence on these factors.

Mechanical stress driven by rigidity sensing governs epithelial stability

The paper shows that substrate stiffness drives mechanical switches in epithelial monolayers, leading to stochastic failure through topological defects.

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division

This study shows OPTN regulates bacterial invasion by linking HACE1-mediated Rac1 ubiquitylation to integrin mechanotransduction and ECM stiffness.

Mechanics defines the spatial pattern of compensatory proliferation

The paper identifies that spatial inhomogeneity in mechanotransduction via YAP drives compensatory proliferation in response to apoptosis.

Bioengineering a Miniaturized In Vitro 3D Myotube Contraction Monitoring Chip For Modelization of Muscular Dystrophies

This paper develops a miniaturized 3D myotube contraction monitoring chip to model muscular dystrophies, showing contractile dysfunction in L-CMD mutant myotubes with reduced starting material requirements.

Cell motility driven by long-lived spatial memory

This study shows cells retain memory of their path through physicochemical footprints, leading to self-interacting random walks and altered space exploration.

Nature of active forces in tissues: how contractile cells can form extensile monolayers

The paper investigates how epithelial cell monolayers switch from extensile to contractile behavior as intercellular contacts weaken, revealing mechanotransductive responses and implications for cell sorting and tissue dynamics.

Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion

This study identifies a dual-mode actin mechanism involving lamellipodia protrusions and purse-string contractility that drives apoptotic cell extrusion in epithelia.

Endosomal spatio-temporal modulation of the cortical RhoA zone conditions epithelial cell organization

This study shows EpCAM regulates RhoA trafficking via endosomes to control actomyosin dynamics, cell shape, and polarity in epithelial cells.

Desmosomal coupling in apoptotic cell extrusion

This study shows that desmosomal junctions remain intact during apoptotic cell extrusion and are crucial for the process, with actomyosin cables interacting mechanically with desmosomes.

Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration

This study shows that collective cell migration in epithelial monolayers arises from single-cell polarity signals rather than cell-cell junctions.

Enhanced cell-cell contact stability upon Fibroblast Growth factor Receptor/N-cadherin cross-talk

This study shows FGFR1 stabilizes N-cadherin at cell-cell contacts, enhancing adhesion and reducing cell migration through Src and p120 pathways.

Caveolae set levels of epithelial monolayer tension to eliminate tumor cells

The paper shows caveolae regulate epithelial tension through lipid signaling, enabling the elimination of oncogene-transformed cells by apical extrusion.

Myosin II isoforms play distinct roles in adherens junction biogenesis

This study identifies distinct roles of myosin II isoforms in adherens junction biogenesis, showing NMIIA provides mechanical force for junction maintenance while NMIIB facilitates E-cadherin clustering and anisotropic stress.

Sustained oscillations of epithelial cell sheets

This study identifies a novel mode of collective oscillations in epithelial cell sheets under confinement, showing that oscillatory motion drives cellular movements and is regulated by confinement dimensions and force transmission.

Local Contractions Regulate E-Cadherin Adhesions, Rigidity Sensing and Epithelial Cell Sorting

The paper shows that local contractions regulate E-cadherin adhesions, rigidity sensing, and epithelial cell sorting through mechanical testing of neighboring cells.

Force-Dependent Binding Of Vinculin To α-catenin Regulates Cell-Cell Contacts Stability And Collective Cell Behavior

This study shows that force-dependent vinculin binding to α-catenin stabilizes adherens junctions and regulates cell-cell contact dynamics and collective cell behavior.

Collective cell migration without proliferation: density determines cell velocity and wave velocity

This study investigates collective cell migration by analyzing how cell density affects velocity and wave propagation in epithelial monolayers.