R.-M. Mege

The adherens junction proteins α-catenin, vinculin and VASP cooperate to promote actin assembly

This study investigates how α-catenin, vinculin, and VASP work together in a complex to regulate actin assembly during adherens junction formation.

Mechanical stress driven by rigidity sensing governs epithelial stability

The paper shows that substrate stiffness drives mechanical switches in epithelial monolayers, leading to stochastic failure through topological defects.

Cell motility driven by long-lived spatial memory

This study shows cells retain memory of their path through physicochemical footprints, leading to self-interacting random walks and altered space exploration.

Nature of active forces in tissues: how contractile cells can form extensile monolayers

The paper investigates how epithelial cell monolayers switch from extensile to contractile behavior as intercellular contacts weaken, revealing mechanotransductive responses and implications for cell sorting and tissue dynamics.

Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion

This study identifies a dual-mode actin mechanism involving lamellipodia protrusions and purse-string contractility that drives apoptotic cell extrusion in epithelia.

Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration

This study shows that collective cell migration in epithelial monolayers arises from single-cell polarity signals rather than cell-cell junctions.

Enhanced cell-cell contact stability upon Fibroblast Growth factor Receptor/N-cadherin cross-talk

This study shows FGFR1 stabilizes N-cadherin at cell-cell contacts, enhancing adhesion and reducing cell migration through Src and p120 pathways.

Myosin II isoforms play distinct roles in adherens junction biogenesis

This study identifies distinct roles of myosin II isoforms in adherens junction biogenesis, showing NMIIA provides mechanical force for junction maintenance while NMIIB facilitates E-cadherin clustering and anisotropic stress.

Sustained oscillations of epithelial cell sheets

This study identifies a novel mode of collective oscillations in epithelial cell sheets under confinement, showing that oscillatory motion drives cellular movements and is regulated by confinement dimensions and force transmission.

Local Contractions Regulate E-Cadherin Adhesions, Rigidity Sensing and Epithelial Cell Sorting

The paper shows that local contractions regulate E-cadherin adhesions, rigidity sensing, and epithelial cell sorting through mechanical testing of neighboring cells.

Force-Dependent Binding Of Vinculin To α-catenin Regulates Cell-Cell Contacts Stability And Collective Cell Behavior

This study shows that force-dependent vinculin binding to α-catenin stabilizes adherens junctions and regulates cell-cell contact dynamics and collective cell behavior.