Author

J. P. Roose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Sil· 2 shared C. R. Langelier· 2 shared L. Hysenaj· 2 shared L. Rodriguez· 2 shared M. Ott· 2 shared A. A. Rao· 1 shared A. J. Combes· 1 shared A. Marson· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

A. Sil

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Immediate myeloid depot for SARS-CoV-2 in the human lung

M. Magnen, R. You, A. A. Rao, R. T. Davis, L. Rodriguez, C. R. Simoneau, L. Hysenaj, K. H. Hu, The UCSF COMET Consortium, C. Love, P. G. Woodruff, D. J. Erle, C. M. Hendrickson, C. S. Calfee, M. A. Matthay, , M. R. Looney

The paper investigates early SARS-CoV-2 infection in human lung myeloid cells, finding rapid viral tropism, ACE2 dependence, and poor interferon induction, suggesting a myeloid depot for viral persistence.

bioRxiv · Apr 28, 2022Immunology

A focal adhesion kinase-YAP signaling axis drives drug tolerant persister cells and residual disease in lung cancer

F. Haderk, C. Fernandez-Mendez, L. Cech, J. Yu, I. M. Meraz, V. Olivas, D. Barbosa Rabago, D. L. Kerr, C. Gomez, D. V. Allegakoen, J. Guan, K. N. Shah, K. A. Herrington, O. M. Gbenedio, S. Nanjo, , T. G. Bivona

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

bioRxiv · Oct 23, 2021Cancer Biology

SARS-CoV-2 infection studies in lung organoids identify TSPAN8 as novel mediator

L. Hysenaj, S. Little, K. R. Kulhanek, O. Gbenedio, L. Rodriguez, A. Shen, J.-C. Lone, L. C. Lupin-Jimenez, L. Bonser, N. K. Serwas, K. Bahl, E. Mick, J. Z. Li, V. Ding, S. Matsumoto, , J. P. Roose

The paper identifies TSPAN8 as a novel mediator of SARS-CoV-2 infection in lung organoids, showing its correlation with infection rates and susceptibility to blocking antibodies.

bioRxiv · Jun 1, 2021 · PreprintMicrobiology

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

M. Baars, T. Douma, D. R. Simeonov, D. R. Myers, S. Banerjee, K. Kulhanek, S. Zwakenberg, M. P. Baltissen, S. de Roock, F. van Wijk, M. Vermeulen, A. Marson, J. P. Roose, Y. Vercoulen

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

bioRxiv · Nov 8, 2019Immunology