Author

D. R. Simeonov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Marson· 3 shared A. C. Indart· 2 shared A. Young· 2 shared H. S. Wong· 2 shared J. T. Cortez· 2 shared J. Umhoefer· 2 shared K. Park· 2 shared M. S. Anderson· 2 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

A. Marson

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3 papers

Recent·Most cited

Non-coding sequence variation reveals fragility within interleukin 2 feedback circuitry and shapes autoimmune disease risk

D. R. Simeonov, K. Park, J. T. Cortez, A. Young, Z. Li, V. Nguyen, J. Umhoefer, A. C. Indart, J. Woo, M. S. Anderson, J. S. Tsang, R. N. Germain, H. S. Wong, A. Marson

The paper shows how non-coding variants affecting IL2RA enhancers alter T cell feedback circuits, leading to opposing autoimmune outcomes in mice.

bioRxiv · Jun 17, 2023 · PreprintImmunology

T cell subset-selective IL2RA enhancers shape autoimmune diabetes risk

D. R. Simeonov, H. S. Wong, J. T. Cortez, A. Young, Z. Li, V. Nguyen, K. Park, J. Umhoefer, A. C. Indart, J. M. Woo, M. S. Anderson, R. N. Germain, A. Marson

This study identifies two enhancers regulating IL2RA expression in T cells, showing how their cell-type-specific effects influence autoimmune diabetes risk.

bioRxiv · Jul 22, 2020 · PreprintImmunology

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

M. Baars, T. Douma, D. R. Simeonov, D. R. Myers, S. Banerjee, K. Kulhanek, S. Zwakenberg, M. P. Baltissen, S. de Roock, F. van Wijk, M. Vermeulen, A. Marson, J. P. Roose, Y. Vercoulen

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

bioRxiv · Nov 8, 2019Immunology