Author

S. Zwakenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

A. Fasano· 1 shared A. M. Lozano· 1 shared A. Marson· 1 shared B. M. T. Burgering· 1 shared C. Burns· 1 shared C. S. Asensio· 1 shared C. Sepulveda· 1 shared C. ten Brink· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCell Biology

A. Fasano

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Author profile →

3 papers

Recent·Most cited

Mitochondrial H2O2 release does not directly cause genomic DNA damage.

D. M. K. van Soest, P. E. Polderman, W. T. den Toom, S. Zwakenberg, S. De Henau, B. M. T. Burgering, T. B. Dansen

This study shows that mitochondrial H2O2 release does not directly cause genomic DNA damage, as it instead triggers ferroptosis and prevents mutation propagation.

bioRxiv · Mar 29, 2023Cell Biology

VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling

R. E. N. van der Welle, R. Jobling, C. Burns, P. Sanza, C. ten Brink, A. Fasano, L. Chen, F. J. Zwartkruis, S. Zwakenberg, E. F. Griffin, J. van der Beek, T. Veenendaal, N. Liv, S. Blaser, C. Sepulveda, , J. Klumperman

This paper identifies VPS41 mutations causing neurodegenerative disease by disrupting HOPS function and mTORC1 signaling, leading to lysosomal dysfunction and impaired autophagy.

bioRxiv · Dec 18, 2019 · PreprintCell Biology

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

M. Baars, T. Douma, D. R. Simeonov, D. R. Myers, S. Banerjee, K. Kulhanek, S. Zwakenberg, M. P. Baltissen, S. de Roock, F. van Wijk, M. Vermeulen, A. Marson, J. P. Roose, Y. Vercoulen

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

bioRxiv · Nov 8, 2019Immunology