S. Siddiqui

The incidence of movement disorders increases with age and contrasts with subtle and limited neuroimaging abnormalities in argininosuccinic aciduria.

This study investigates movement disorders in argininosuccinic aciduria (ASA), finding they increase with age and show specific neuroimaging abnormalities not seen in mouse models.

Multiplexed Sequential Imaging in Living Cells with Orthogonal Fluorogenic RNA Aptamer/Dye Pairs

This paper introduces seqFRIES, a method for multiplexed live-cell imaging using orthogonal RNA aptamer/dye pairs, achieving four-color imaging in ~20 minutes.

Ex vivo primary liver sections recapitulate disease phenotype and therapeutic rescue for liver monogenic diseases

This study uses precision-cut liver sections from mice to model monogenic liver diseases and test gene therapy efficacy.

Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity and neutralization sensitivity

This study investigates how mutations in the S2 subunit of SARS-CoV-2 Omicron spike affect its structure, fusogenicity, and neutralization sensitivity.

Quantitative Nanohistology of aging dermal collagen

This study uses atomic force microscopy to analyze collagen fibrils in skin samples from different age groups and anatomical sites, identifying age-related structural biomarkers in dermal collagen.

Tumor-targeted delivery of childhood vaccine recall antigens by attenuated Listeria reduces pancreatic cancer

This study shows that delivering a childhood vaccine antigen via attenuated Listeria improves immunotherapy for pancreatic cancer by converting cold tumors into hot tumors and enhancing T cell activity.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype

This paper shows that repeated Plasmodium falciparum infections reprogram human monocytes to a regulatory phenotype, reducing inflammatory responses during subsequent infections.

Multiomics integrative analysis reveals antagonistic roles of CBX2 and CBX7 in metabolic reprogramming of breast cancer

The paper identifies antagonistic roles of CBX2 and CBX7 in breast cancer metabolism using multi-omics data and validates their impact on tumor aggressiveness and drug response.

Integrated sample inactivation, amplification, and Cas13-based detection of SARS-CoV-2

This paper develops SHINE, a diagnostic tool for SARS-CoV-2 detection with 90% sensitivity and 100% specificity, reducing contamination risk and enabling use outside clinical settings.

Factors Affecting Detection Of GMO Traces In Food And Crop Samples

This study examines factors affecting the detection of GM rice, showing that husk presence, DNA extraction methods, and PCR primers significantly influence detection outcomes.

Policy lessons from spatiotemporal enrollment patterns of Payment for Ecosystem Service Programs in Argentina

This paper analyzes spatiotemporal enrollment patterns in Argentina's PES program to identify adverse selection and proposes strategies to improve conservation outcomes.