Author

R. Guha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

C. Klumpp-Thomas· 2 shared M. D. Hall· 2 shared M. Shen· 2 shared O. W. Lee· 2 shared T. D. Lee· 2 shared A. Mathioudaki· 1 shared A. Ongoiba· 1 shared A. Sen· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

C. Klumpp-Thomas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Plasmodium falciparum malaria drives epigenetic reprogramming of human monocytes toward a regulatory phenotype

R. Guha, A. Mathioudaki, S. Doumbo, D. Doumtabe, J. Skinner, G. Arora, S. Siddiqui, S. Li, K. Kayentao, A. Ongoiba, J. B. Zaugg, B. Traore, P. D. Crompton

This paper shows that repeated Plasmodium falciparum infections reprogram human monocytes to a regulatory phenotype, reducing inflammatory responses during subsequent infections.

bioRxiv · Oct 21, 2020Immunology

Non-uniform Crowding Enhances Transport: Relevance to Biological Environments

M. Collins, F. Mohajerani, S. Ghosh, R. Guha, T.-H. Lee, P. J. Butler, A. Sen, D. Velegol

The paper shows that non-uniform crowder distributions enhance tracer transport in biological environments, with implications for intracellular transport mechanisms.

bioRxiv · Mar 31, 2019 · PreprintBiophysics

Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening

O. W. Lee, S. M. Austin, M. R. Gamma, D. M. Cheff, T. D. Lee, K. M. Wilson, J. M. Johnson, J. C. Travers, J. C. Braisted, R. Guha, C. Klumpp-Thomas, M. Shen, M. D. Hall

The paper profiles cytotoxicity of over 100,000 compounds across normal and cancer cell lines to identify cytotoxic compounds and improve screening efficiency.

bioRxiv · Feb 5, 2019Cell Biology

A High-Throughput Screen of a Library of Therapeutics Identifies Substrates of P-glycoprotein

T. D. Lee, O. W. Lee, K. R. Brimacombe, L. Chen, R. Guha, S. Lusvarghi, B. G. Tebase, C. Klumpp-Thomas, R. W. Robey, S. V. Ambudkar, M. Shen, M. M. Gottesman, M. D. Hall

This paper identifies 90 P-gp substrates from 10,804 compounds using a high-throughput screen, including 55 new substrates confirmed by orthogonal assays.

bioRxiv · Jan 23, 2019Pharmacology & Toxicology