K. Miura

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa

This paper evaluates the cross-reactivity of a recombinant Plasmodium vivax protein with sera from Plasmodium falciparum-exposed individuals and demonstrates its transmission-blocking activity against P. falciparum.

A novel method for fine-scale retrospective isotope analysis in mammals using eye lenses

This study introduces a method to reconstruct brown bear dietary history using eye lens isotopes, showing age-related dietary shifts and corn consumption patterns.

Evaluation of Precision of the Plasmodium knowlesi Growth Inhibition Assay for Plasmodium vivax Duffy-Binding Protein-based Malaria Vaccine Development

This study evaluates the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development, finding significant assay-to-assay variation in %GIA and GIA50.

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

Multiple stressors and recruitment failure of long-lived endangered freshwater mussels with a complex life cycle

This study investigates how multiple stressors affect recruitment efficiency in endangered freshwater mussels, identifying parasitic and post-parasitic juvenile stages as critical bottlenecks.

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

Mesenchymal stem cells of the bone marrow raise infectivity of Plasmodium falciparum gametocytes

This study shows that bone marrow mesenchymal stem cells increase the infectivity of Plasmodium falciparum gametocytes, enhancing mosquito infection rates.

Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites

This study identifies antibody gene features linked to binding and functional activity in vaccine-derived human mAbs against malaria parasites, showing adjuvant effects on clonotype diversity.

Recruitment status and host-fish-limitation threats to endangered freshwater pearl mussel (Margaritifera laevis) in eastern Hokkaido, northern Japan

The paper assesses recruitment status and host-fish limitation threats to endangered freshwater pearl mussels in eastern Hokkaido, finding low juvenile proportions and a positive link between juvenile presence and host-fish density.

Blue light promotes ascorbate synthesis by deactivating the PAS/LOV photoreceptor that inhibits GDP-L-galactose phosphorylase

The paper identifies a photoreceptor, PLP, that inhibits ascorbate biosynthesis by interacting with GGP, and shows blue light deactivates PLP to promote ascorbate synthesis in tomato.

Relationship between salmon egg subsidy and the distribution of an avian predator

The paper examines how salmon egg availability affects brown dipper abundance and distribution, finding a strong correlation with spawning redds.

Identification of a Prunus MAX1 Homolog as a Unique Strigol Synthase from Carlactone Bypassing 5-Deoxystrigol

The paper identifies a Prunus MAX1 homolog as a strigol synthase that bypasses 5-deoxystrigol synthesis, directly converting carlactone to strigol.

Structure of the malaria vaccine candidate Pfs48/45 and its recognition by transmission blocking antibodies

This study determines the structure of Pfs48/45, a malaria vaccine candidate, and identifies antibody binding sites that block parasite transmission.

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats

This study shows naked mole-rats (NMRs) resist chemical carcinogenesis through reduced inflammatory responses linked to necroptosis deficiency.

Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.

The paper identifies key residues and an acyl-CoA-binding pocket in mouse LPCAT2 using homology modeling, providing structural insights for drug development against PAF-related diseases.

Senescent cell death as an aging resistance mechanism in naked mole-rat

This study identifies senescent cell death as a mechanism contributing to the aging resistance in naked mole-rats, linking low antioxidant defense with suppressed senescent cell accumulation.

Tunica intima compensation for reduced stiffness of the tunica media in aging renal arteries as measured with scanning acoustic microscopy

This study uses scanning acoustic microscopy to analyze structural and mechanical changes in aging renal arteries, finding that the tunica intima compensates for reduced stiffness in the tunica media.

Common properties of visually-guided saccadic behavior and bottom-up attention in marmoset, macaque, and human

This study compares saccadic behavior and bottom-up attention across marmoset, macaque, and human in free-viewing and visually-guided tasks, finding similar kinematics and saliency responses.

Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a poikilothermic mammal

This study investigates brown adipose tissue thermogenesis in naked mole-rats, showing ADRB3-dependent thermogenic activity and its role in thermoregulation in non-cold environments.

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

Plasmodium falciparum population genetic complexity influences transcriptional profile and immune recognition of highly related genotypic clusters

The paper examines how changes in Plasmodium falciparum genetic complexity affect transcriptional profiles and immune recognition of genotypic clusters.

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

This study evaluates a novel virus-like particle platform for malaria vaccines, showing immunogenicity and transmission-blocking activity against Pfs230 and Pfs25 antigens.