A. Harada

Precise immunofluorescence canceling for highly multiplexed imaging capturing specific cell state

The paper introduces PECAbs for high-specificity multiplexed imaging of cell states and combines them with seq-smFISH to classify cells and identify signal activation states in human tissue.

The anti-tumor effect of trifluridine via induction of aberrant mitosis is unaffected by mutations modulating p53 activity

This study shows that trifluridine induces aberrant mitosis and cytotoxicity in both p53-null and p53-GOF mutant cells, independent of p53 function.

Loss of Rab8a in B cells leads to increased antibody responses and class-switch recombination

This study shows that Rab8a deficiency in B cells increases antibody responses and class-switch recombination by altering signaling pathways.

Evaluation of the Efficacy and Safety of a Clinical Grade Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Patch: A Pre-Clinical Study

This pre-clinical study evaluates the safety and efficacy of clinical-grade human iPSC-derived cardiomyocyte patches in treating heart failure, showing improved cardiac function and no adverse effects.

Recruitment of KRAS downstream target ARL4C to membrane protrusions accelerates pancreatic cancer cell invasion.

This study identifies ARL4C's role in pancreatic cancer invasion by localizing it to membrane protrusions and showing its interaction with IQGAP1 and MMP14, leading to extracellular matrix degradation and metastasis suppression via ASO.

Activity-specificity trade-off gives PI5P4Kβ a nucleotide preference to function as a GTP-sensing kinase.

This study identifies the TRNVF motif as responsible for PI5P4Kβ's GTP binding and extended specificity to ITP and XTP, showing how its GTP preference allows it to function as a GTP sensor despite low cellular concentrations of ITP and XTP.

Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay

The paper develops a method to study histone variant incorporation and finds that chromatin structure and DNA replication influence histone deposition patterns.