Arrested Agonist Paradigm For Selective Radiosensitization of Prostate Cancer
J. B. Coulter, M. Haffner, Y. Zhang, H. Zhou, M.-T. N. Pham, J. Chen, R. Chikarmane, A. Mishra, M. S. Mehl, S. Kazibwe, K. Choi, A. Archey, S. Valluri, S. E. Lupold, D. Song, , S. Yegnasubramanian
This paper identifies hydroxyflutamide as an AR arrested agonist that induces DNA damage in prostate cancer cells, enabling selective radiosensitization without promoting growth.
bioRxiv · Oct 1, 2023 · PreprintCancer Biology