Author

S. KC

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

T. C. Boothby· 4 shared A. S. Holehouse· 3 shared S. Biswas· 3 shared S. Sukenik· 3 shared E. Gollub· 2 shared E. W. Martin· 2 shared F. Francia· 2 shared F. Yu· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersBiochemistry

T. C. Boothby

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Disordered proteins interact with the chemical environment to tune their protective function during drying

S. KC, K. H. Nguyen, V. Nicholson, A. Walgren, T. Trent, E. Gollub, S. Ramero, A. S. Holehouse, S. Sukenik, T. C. Boothby

This study investigates how disordered proteins interact with endogenous cosolutes during drying to enhance desiccation protection across different organisms.

bioRxiv · Feb 28, 2024Biochemistry

Labile assembly of a tardigrade protein induces biostasis

S. Sanchez-Martinez, K. Nguyen, S. Biswas, V. Nicholson, A. V. Romanyuk, J. F. Ramirez, S. KC, A. Akter, C. Childs, E. T. Usher, G. M. Ginell, F. Yu, E. Gollub, M. Malferrari, F. Francia, , T. C. Boothby

This study identifies a mechanism by which tardigrade CAHS D proteins form gels to protect cells during desiccation, showing that gelation reduces molecular motion and metabolic activity, with reversible effects.

bioRxiv · Jun 30, 2023Physiology

Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state

M. H. Packebush, S. Sanchez-Martinez, S. Biswas, S. KC, K. Nguyen, T. C. Boothby

This study shows that natural and engineered desiccation-tolerant mediators can stabilize Human Blood Clotting Factor VIII without cold-chain storage.

bioRxiv · Nov 28, 2022 · PreprintPharmacology & Toxicology

Tardigrade CAHS Proteins Act as Molecular Swiss Army Knives to Mediate Desiccation Tolerance Through Multiple Mechanisms

C. S. Hesgrove, K. H. Nguyen, S. Biswas, C. A. Childs, S. KC, B. X. Medina, V. Alvarado, S. Sukenik, F. Yu, M. Malferrari, F. Francia, G. Venturoli, E. W. Martin, A. S. Holehouse, T. C. Boothby

This study identifies CAHS D as a tardigrade protein that protects against desiccation through multiple mechanisms involving water coordination and slowed molecular motion.

bioRxiv · Aug 16, 2021 · PreprintBiophysics