Author

P.-J. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Organism:virus· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:phylogenetics / evolution· 2 Research Focus:genome assembly· 1

Frequent Co-Authors

S.-H. Yeh· 5 shared S.-Y. Chang· 5 shared H.-Y. Wang· 4 shared J.-H. Tai· 4 shared S.-M. Chaw· 3 shared H.-F. Lin· 2 shared T.-L. Chao· 2 shared Y.-W. Cheng· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersEvolutionary Biology

S.-H. Yeh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

D.-C. Lee, J.-H. Tai, H.-F. Lin, T.-L. Chao, Y. Ruan, Y.-W. Cheng, Y.-C. Chou, Y.-Y. Lin, S.-Y. Chang, P.-J. Chen, S.-H. Yeh, H.-Y. Wang

The paper examines how antagonistic pleiotropy influences SARS-CoV-2 evolution and genetic diversity by analyzing genomic mutations and their functional impacts.

bioRxiv · Feb 10, 2023Evolutionary Biology

Spatial and Temporal Origin of The Third SARS-Cov-2 Outbreak in Taiwan

J.-H. Tai, Y. K. Low, S. C.-L. Wang, H.-F. Lin, T.-Y. Wang, Y.-Y. Lin, C. Foster, S. J. van Hal, Y.-Y. Lai, S.-H. Yeh, S.-Y. Chang, P.-J. Chen, S.-M. Chaw

This study identifies the third SARS-CoV-2 outbreak in Taiwan as originating from a European lineage introduced in February 2021, not from the US as previously thought.

bioRxiv · Jul 4, 2022 · PreprintEvolutionary Biology

Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1

J. Leandro, S. Khamrui, C. Suebsuwong, P.-J. Chen, C. Secor, T. Dodatko, C. Yu, R. Sanchez, R. DeVita, S. Houten, M. Lazarus

The paper characterizes the human LOR domain of AASS, presents its crystal structure, and identifies it as a potential drug target for glutaric aciduria type 1.

bioRxiv · May 20, 2022Biochemistry

Signatures of adaptive evolution during human to mink SARS CoV2 cross species transmission inform estimates of the COVID19 pandemic timing

J.-H. Tai, S.-M. Chaw, H.-Y. Sun, Y.-C. Tseng, G. Li, S.-Y. Chang, S.-H. Yeh, P.-J. Chen, H.-Y. Wang

The paper analyzes SARS-CoV-2 sequences from minks and humans to determine if adaptive evolution occurred before the pandemic, suggesting the virus may have circulated in humans for at least six months prior to the Wuhan outbreak.

bioRxiv · Sep 15, 2021 · PreprintEvolutionary Biology

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Viral Transmission via Enhanced Furin-mediated Spike Cleavage

Y.-W. Cheng, T.-L. Chao, C.-L. Li, S.-H. Wang, H.-C. Kao, Y.-M. Tsai, H.-Y. Wang, C.-L. Hsieh, P.-J. Chen, S.-Y. Chang, S.-H. Yeh

This study shows the D614G substitution in SARS-CoV-2 spike protein increases viral transmission by enhancing furin-mediated cleavage, leading to more syncytium formation and higher virus titers.

bioRxiv · Jan 27, 2021Microbiology

The origin and underlying driving forces of the SARS-CoV-2 outbreak

S.-M. Chaw, J.-H. Tai, S.-L. Chen, C.-H. Hsieh, S.-Y. Chang, S.-H. Yeh, W.-S. Yang, P.-J. Chen, H.-Y. Wang

This paper analyzes SARS-CoV-2 genetic variation and finds evidence of intergenomic recombination, relaxed selection, and possible cryptic circulation in humans before the 2020 outbreak.

bioRxiv · Apr 12, 2020Evolutionary Biology