Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics
K. E. Ankenbauer, T. C. Rao, A. L. Mattheyses, S. L. Bellis
This study shows that ST6GAL1-mediated 2,6 sialylation of EGFR enhances receptor activation, dimerization, and recycling while inhibiting lysosomal degradation.
bioRxiv · Jun 3, 2023Cell Biology