S. L. McKnight

Functional Anatomy of the TDP-43 Redox Sensor

This study investigates the role of individual hydrogen bonds in facilitating the self-adherence of the TDP-43 low complexity domain.

The Low Complexity Domain of the FUS RNA Binding Protein Self-assembles via the Mutually Exclusive Use of Two Distinct Cross-β Cores

This paper identifies two distinct cross-β cores in the FUS LC domain that function mutually exclusively, and shows disease mutations disrupt this balance.

Dynamic structural order of a low complexity domain facilitates assembly of intermediate filaments

The paper shows that low complexity domains in Drosophila Tm1 proteins form labile cross-β interactions, facilitating intermediate filament assembly through dynamic structural transitions.

Transiently structured head domains control intermediate filament assembly

This study shows how low complexity head domains transiently form structured β-strand-enriched polymers that influence intermediate filament assembly and cell morphology.

Redox-mediated regulation of a labile, evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain

This study shows that redox regulation controls TDP43 low complexity domain aggregation into cross-β polymers, with implications for neurodegenerative diseases.