Author

S. Loontiens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

F. Speleman· 4 shared E. Sanders· 3 shared P. Van Vlierberghe· 3 shared A. Eggermont· 2 shared A. Louwagie· 2 shared B. Decaesteker· 2 shared C. Van Neste· 2 shared F. Van Nieuwerburgh· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCancer Biology

F. Speleman

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Author profile →

4 papers

Recent·Most cited

The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA

L. Depestel, S.-L. Bekaert, E. Sanders, C. Van Damme, A. Eggermont, S. Loontiens, L. Tilleman, F. Van Nieuwerburgh, L. Delhaye, P. Van Vlierberghe, S. Eyckerman, F. Speleman, K. Durinck

This study identifies PHF6's interaction with RRM2 and its binding to H3K56ac marked nascent DNA, revealing a role in replication fork restart and DNA damage repair.

bioRxiv · Mar 8, 2023 · PreprintCancer Biology

MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma

E. Fredlund, S. Andersson, E. Hilgert, G. Alvarez-Hernan, E. Monferrer, S. Karakaya, T. Gregor, S. Loontiens, J. W. Bek, E. Lecomte, E. Magnusson, E. Miltenyte, M. Cabirol, M. Kyknas, N. Engstrom, , S. Mohlin

The paper identifies MOXD1 as a tumor-suppressor gene in neuroblastoma by analyzing bulk and single-cell RNA sequencing data and validating its role in organ homeostasis across multiple species.

bioRxiv · Jan 17, 2023 · PreprintCancer Biology

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

C. Nunes, L. Depestel, L. M. Mus, K. M. Keller, L. Delhaye, A. Louwagie, M. Rishfi, E. M. Dolman, V. Olexiouk, C. Bartenhagen, F. Devloed, E. Sanders, A. Eggermont, J. Van Laere, E. De Smet, , F. Speleman

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

bioRxiv · Nov 25, 2020 · PreprintCancer Biology

SOX11 is a lineage-dependency factor and master epigenetic regulator in neuroblastoma

B. Decaesteker, A. Louwagie, S. Loontiens, F. De Vloed, J. Roels, S. Vanhauwaert, S. De Brouwer, E. Sanders, G. Denecker, E. D'haene, S. Van Haver, W. Van Loocke, J. Van Dorpe, D. Creytens, N. Van Roy, , F. Speleman

This study identifies SOX11 as a critical transcription factor and epigenetic regulator in adrenergic neuroblastoma, showing its role in chromatin accessibility and cell identity.

bioRxiv · Aug 21, 2020 · PreprintCancer Biology