Author

K. Durinck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

F. Speleman· 4 shared F. Van Nieuwerburgh· 4 shared B. Decaesteker· 3 shared C. Van Neste· 3 shared D. Deforce· 3 shared E. Sanders· 3 shared L. M. Mus· 3 shared L. Tilleman· 3 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

F. Speleman

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Author profile →

4 papers

Recent·Most cited

The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA

L. Depestel, S.-L. Bekaert, E. Sanders, C. Van Damme, A. Eggermont, S. Loontiens, L. Tilleman, F. Van Nieuwerburgh, L. Delhaye, P. Van Vlierberghe, S. Eyckerman, F. Speleman, K. Durinck

This study identifies PHF6's interaction with RRM2 and its binding to H3K56ac marked nascent DNA, revealing a role in replication fork restart and DNA damage repair.

bioRxiv · Mar 8, 2023 · PreprintCancer Biology

MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells

S. Zanotti, S. Vanhauwaert, C. Van Neste, V. Olexiouk, J. Van Laere, M. Verschuuren, L. M. Mus, K. Durinck, L. Tilleman, D. Deforce, F. Van Nieuwerburgh, M. D. Hogarty, B. Decaesteker, W. H. De Vos, F. Speleman

This study shows that MYCN activation in RPE cells causes nucleolar stress and a senescence-like transcriptional program without full senescence hallmarks, leading to growth attenuation.

bioRxiv · Jan 22, 2021Cancer Biology

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

C. Nunes, L. Depestel, L. M. Mus, K. M. Keller, L. Delhaye, A. Louwagie, M. Rishfi, E. M. Dolman, V. Olexiouk, C. Bartenhagen, F. Devloed, E. Sanders, A. Eggermont, J. Van Laere, E. De Smet, , F. Speleman

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

bioRxiv · Nov 25, 2020 · PreprintCancer Biology

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

L. M. Mus, S. Van Haver, M. Popovic, W. Trypsteen, S. Lefever, N. Zeltner, Y. Ogando, E. Z. Jacobs, G. Denecker, E. Sanders, C. Van Neste, S. Vanhauwaert, B. Decaesteker, D. Deforce, F. Van Nieuwerburgh, , F. Speleman

This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.

bioRxiv · Nov 6, 2020Cancer Biology