Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
8 papers
Recent·Most cited
J. Gabre, P. Merseburger, A. Claeys, J. Siaw, S.-L. Bekaert, F. Speleman, B. Hallberg, R. Palmer, J. Van den Eynden
The paper introduces CLEAN, a web tool for exploring neuroblastoma data, focusing on DNA damage response to identify drug targets.
bioRxiv · Sep 17, 2023Cancer Biology
L. Depestel, S.-L. Bekaert, E. Sanders, C. Van Damme, A. Eggermont, S. Loontiens, L. Tilleman, F. Van Nieuwerburgh, L. Delhaye, P. Van Vlierberghe, S. Eyckerman, F. Speleman, K. Durinck
This study identifies PHF6's interaction with RRM2 and its binding to H3K56ac marked nascent DNA, revealing a role in replication fork restart and DNA damage repair.
bioRxiv · Mar 8, 2023 · PreprintCancer Biology
E. Fredlund, S. Andersson, E. Hilgert, G. Alvarez-Hernan, E. Monferrer, S. Karakaya, T. Gregor, S. Loontiens, J. W. Bek, E. Lecomte, E. Magnusson, E. Miltenyte, M. Cabirol, M. Kyknas, N. Engstrom, , S. Mohlin
The paper identifies MOXD1 as a tumor-suppressor gene in neuroblastoma by analyzing bulk and single-cell RNA sequencing data and validating its role in organ homeostasis across multiple species.
bioRxiv · Jan 17, 2023 · PreprintCancer Biology
S. Zanotti, S. Vanhauwaert, C. Van Neste, V. Olexiouk, J. Van Laere, M. Verschuuren, L. M. Mus, K. Durinck, L. Tilleman, D. Deforce, F. Van Nieuwerburgh, M. D. Hogarty, B. Decaesteker, W. H. De Vos, F. Speleman
This study shows that MYCN activation in RPE cells causes nucleolar stress and a senescence-like transcriptional program without full senescence hallmarks, leading to growth attenuation.
bioRxiv · Jan 22, 2021Cancer Biology
C. Nunes, L. Depestel, L. M. Mus, K. M. Keller, L. Delhaye, A. Louwagie, M. Rishfi, E. M. Dolman, V. Olexiouk, C. Bartenhagen, F. Devloed, E. Sanders, A. Eggermont, J. Van Laere, E. De Smet, , F. Speleman
This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.
bioRxiv · Nov 25, 2020 · PreprintCancer Biology
L. M. Mus, S. Van Haver, M. Popovic, W. Trypsteen, S. Lefever, N. Zeltner, Y. Ogando, E. Z. Jacobs, G. Denecker, E. Sanders, C. Van Neste, S. Vanhauwaert, B. Decaesteker, D. Deforce, F. Van Nieuwerburgh, , F. Speleman
This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.
bioRxiv · Nov 6, 2020Cancer Biology
B. Decaesteker, A. Louwagie, S. Loontiens, F. De Vloed, J. Roels, S. Vanhauwaert, S. De Brouwer, E. Sanders, G. Denecker, E. D'haene, S. Van Haver, W. Van Loocke, J. Van Dorpe, D. Creytens, N. Van Roy, , F. Speleman
This study identifies SOX11 as a critical transcription factor and epigenetic regulator in adrenergic neuroblastoma, showing its role in chromatin accessibility and cell identity.
bioRxiv · Aug 21, 2020 · PreprintCancer Biology
F. Zeka, A. Van Goethem, K. Vanderheyden, F. Demuynck, T. Lammens, A. Decock, H. H. Helsmoortel, J. Vermeulen, R. Noguera, A. P. Berbegall, V. Combaret, G. Schleiermacher, G. Laureys, A. Schramm, J. H. Schulte, , J. Vandesompele
This study identifies 9 miRNAs associated with metastatic neuroblastoma by analyzing serum miRNome in patient cohorts and xenografted mice.
bioRxiv · Apr 27, 2018Cancer Biology