Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses
C. J. Gordon, S. M. Walker, E. P. Tchesnokov, D. Kocincova, J. Pitts, D. S. Siegel, J. K. Perry, J. Y. Feng, J. P. Bilello, M. Gotte
This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.
bioRxiv · Apr 22, 2024Biochemistry