Y.-M. Kim

Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia

This study identifies impaired vascular endothelial integrity in skeletal muscle as a driver of cancer cachexia and shows that restoring endothelial PGC1 can prevent muscle loss.

Transcriptome Profiling and Characterization of Peritoneal Metastasis Ovarian Cancer Xenografts in Humanized Mice

This study establishes a humanized mouse model of ovarian cancer to evaluate immune checkpoint inhibitor efficacy and identifies gene expression patterns associated with resistance.

Oligosaccharide production and signaling correlate with delayed flowering in an Arabidopsis genotype grown and selected in high

This study compares metabolomic and transcriptomic changes in two Arabidopsis genotypes under elevated CO2, finding that SG delays flowering due to higher oligosaccharide production and altered carbohydrate metabolism.

A novel phenylpropanoid methyl esterase enables catabolism of aromatic compounds that inhibit biological nitrification

The paper identifies a novel phenylpropanoid methyl esterase that catabolizes aromatic biological nitrification inhibitors, enabling their use as carbon sources by bacteria.

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses

This study identifies endothelial mitophagy as a source of mitochondrial formyl proteins that activate neutrophils and contribute to lung inflammation.

Single cell carbon and nitrogen incorporation and remineralization profiles are uncoupled from phylogenetic groupings of diatom-associated bacteria

The paper quantifies single-cell carbon and nitrogen exchange between diatoms and bacteria, finding functional categories not linked to phylogeny.

Metabolomic, photoprotective, and photosynthetic acclimatory responses to post-flowering drought in sorghum

The paper investigates drought tolerance in sorghum by analyzing metabolomic, physiological, and transcriptomic responses to post-flowering drought in two genotypes.

Bulk and spatially resolved extracellular metabolomics of free-living nitrogen fixation

The paper quantifies extracellular metabolites from free-living nitrogen fixation across different environmental structures and scales, revealing nitrogen contributions and highlighting the importance of structural complexity and spatial scale in microbial activity analysis.

A merger between compatible but divergent genomes supports allopolyploidization in the Brassicaceae family

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

Universal gene co-expression network reveals receptor-like protein genes conferring broad-spectrum resistance in pepper (Capsicum annuum L.)

The paper identifies key receptor-like protein genes in pepper that confer broad-spectrum resistance by analyzing co-expression networks across multiple pathogen infections.

Resource reallocation in engineered Escherichia coli strains with reduced genomes

This study examines the effects of genome reduction in E. coli on proteome expression and stability of a biosynthetic pathway for pigment production, finding that proteome fraction elimination impacts fitness and bioproduction balance.

Antibiotic-dependent relationships between nasal microbiome and secreted proteome in chronic rhinosinusitis and nasal polyps

This study examines how antibiotic use affects the nasal microbiome and secreted proteome in chronic rhinosinusitis, finding that antibiotics alter their associations.

A Histoplasma capsulatum lipid metabolic map identifies antifungal targets

This study constructs a lipid metabolic map of Histoplasma capsulatum and identifies potential antifungal drug targets through pathway validation and compound testing.

Multiple reference genome sequences of hot pepper reveal the massive evolution of plant disease resistance genes by retroduplication

The paper reports multiple pepper genomes and finds that retroduplication via LTR-retrotransposons drives expansion of disease resistance genes in plants.