C. Verrill

Novel Methylation Markers in a Prostate Cancer Cohort are Associated with Disease Development and Relapse

The paper identifies novel methylation markers in a prostate cancer cohort associated with disease development and relapse, showing their predictive power for recurrence.

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole genome sequencing with histopathological features

This study integrates multi-region whole genome sequencing with histopathological data to reconstruct tumour phylogenies and identify molecular steps in prostate cancer progression and metastasis.

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

Anti-androgens induce Rab11a-exosome secretion in prostate cancer by suppressing amino acid-sensitive PAT4-mTORC1 signalling

This study shows anti-androgens increase Rab11a-exosome secretion in prostate cancer by inhibiting PAT4-mTORC1 signaling, contributing to drug resistance.

Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection

This study shows that low basal expression and slow induction of IFITM3 in immune cells increases their susceptibility to influenza A virus infection.

Image-based consensus molecular subtype classification (imCMS) of colorectal cancer using deep learning

This paper develops imCMS, a deep learning method to classify colorectal cancer subtypes from histological images, showing improved accuracy over bioinformatic methods.