Author

J. F. DiBerto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:cryo-EM· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. L. Roth· 3 shared S. Chakraborty· 2 shared S. Majumdar· 2 shared T. Che· 2 shared A. B. Pinkerton· 1 shared A. B. Seven· 1 shared A. Faouzi· 1 shared A. Inoue· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

B. L. Roth

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3 papers

Recent·Most cited

Neurotensin receptor allosterism revealed in complex with a biased allosteric modulator

B. E. Krumm, J. F. DiBerto, R. H. J. Olsen, H. J. Kang, S. T. Slocum, S. Zhang, R. T. Strachan, L. M. Slosky, A. B. Pinkerton, L. S. Barak, M. G. Caron, T. Kenakin, B. L. Roth

This study reveals the cryoEM structures of NTSR1 with and without SBI-553, showing its biased allosteric modulation of G protein and β-Arrestin signaling.

bioRxiv · Dec 26, 2022 · PreprintBiophysics

Structural insights into distinct signaling profiles of the μOR activated by diverse agonists

Q. Qu, W. Huang, D. Aydin, J. M. Paggi, A. B. Seven, H. Wang, S. Chakraborty, T. Che, J. F. DiBerto, M. J. Robertson, A. Inoue, B. L. Roth, S. Majumdar, R. O. Dror, B. K. Kobilka, G. Skiniotis

This study compares the structural and signaling differences between two μOR agonists, lofentanil and mitragynine pseudoindoxyl, revealing how their distinct binding modes lead to different G protein and β-arrestin activation profiles.

bioRxiv · Dec 7, 2021 · PreprintBiophysics

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

S. Chakraborty, J. F. Diberto, A. Faouzi, S. M. bernhard, A. M. Gutridge, S. Ramsey, Y. Zhou, D. Provasi, N. Nuthikattu, R. Jilakara, M. Nelson, W. B. Asher, S. O. Eans, L. L. Wilson, S. M. Chintala, , s. majumdar

The paper develops a novel mitragynine analog with reduced mu-opioid receptor efficacy and adverse effects, showing antinociception without respiratory depression or hyperlocomotion.

bioRxiv · Apr 22, 2021Pharmacology & Toxicology