Author

S. P. Goff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Chavez· 2 shared B. Culbertson· 2 shared D. D. Ho· 2 shared M. I. Luck· 2 shared S. Iketani· 2 shared S. J. Hong· 2 shared Y. Sabo· 2 shared A. F. Kratz· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. Chavez

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

S. Iketani, H. Mohri, B. Culbertson, S. J. Hong, Y. Duan, M. I. Luck, M. K. Annavajhala, Y. Guo, Z. Sheng, A.-C. Uhlemann, S. P. Goff, Y. Sabo, H. Yang, A. Chavez, D. D. Ho

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

bioRxiv · Aug 7, 2022Microbiology

Centuries of genome instability and evolution in soft-shell clam transmissible cancer

S. F. Hart, M. A. Yonemitsu, R. M. Giersch, B. F. Beal, G. Arriagada, B. W. Davis, E. A. Ostrander, S. P. Goff, M. J. Metzger

The paper analyzes the genome of a transmissible cancer in soft-shell clams to show its long evolutionary history and structural genomic instability over ~500 years.

bioRxiv · Aug 7, 2022Cancer Biology

The Functional Landscape of SARS-CoV-2 3CL Protease

S. Iketani, S. J. Hong, J. Sheng, F. Bahari, B. Culbertson, F. F. Atanaki, A. K. Aditham, A. F. Kratz, M. I. Luck, R. Tian, S. P. Goff, H. Montazeri, Y. Sabo, D. D. Ho, A. Chavez

This study maps the functional landscape of SARS-CoV-2 3CL protease by profiling all single mutants and identifies resistance mutations to nirmatrelvir.

bioRxiv · Jun 23, 2022 · PreprintMicrobiology

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats

S. P. Goff, S. Winans

This study identifies a point mutation in HIV-1 integrase that shifts integration sites to centromeric repeats, linking it to viral latency and elite controller status.

bioRxiv · Jan 12, 2021Microbiology