Author

H. Mohri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 3 Organism:virus· 2

Frequent Co-Authors

Y. Guo· 5 shared D. D. Ho· 4 shared L. Liu· 4 shared Q. Wang· 4 shared J. Yu· 3 shared S. Iketani· 3 shared Z. Sheng· 3 shared Y. Huang· 2 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersMicrobiology

Y. Guo

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5 papers

Recent·Most cited

Antibody Neutralization of Emerging SARS-CoV-2: EG.5.1 and XBC.1.6

Q. Wang, Y. Guo, R. M. Zhang, J. Ho, H. Mohri, R. Valdez, D. M. Manthei, A. Gordon, L. Liu, D. D. Ho

This study evaluates antibody neutralization resistance of SARS-CoV-2 variants EG.5.1 and XBC.1.6 using pseudovirus assays and sera/mAbs, finding distinct evasion profiles and suggesting immunological imprinting and non-evasion-driven prevalence.

bioRxiv · Aug 21, 2023 · PreprintMicrobiology

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

L. Liu, R. G. Casner, Y. Guo, Q. Wang, S. Iketani, J. F.-W. Chan, J. Yu, B. Dadonaite, M. S. Nair, H. Mohri, E. R. Reddem, S. Yuan, V. K.-M. Poon, C. C.-S. Chan, K.-Y. Yuen, , D. D. Ho

This study identifies two antibodies that neutralize all SARS-CoV-2 variants by locking the spike protein in a down conformation, showing a novel mechanism and potential for prophylaxis.

bioRxiv · Apr 8, 2023 · PreprintMicrobiology

Impaired potency of neutralizing antibodies against cell-cell fusion mediated by SARS-CoV-2

Q. Wang, A. Y. Yeh, Y. Guo, H. Mohri, J. Yu, D. D. Ho, L. Liu

This study develops a high-throughput assay to quantify SARS-CoV-2 spike-mediated cell-cell fusion and finds that it is more resistant to antibody inhibition than cell-free infection.

bioRxiv · Mar 9, 2023Microbiology

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

S. Iketani, H. Mohri, B. Culbertson, S. J. Hong, Y. Duan, M. I. Luck, M. K. Annavajhala, Y. Guo, Z. Sheng, A.-C. Uhlemann, S. P. Goff, Y. Sabo, H. Yang, A. Chavez, D. D. Ho

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

bioRxiv · Aug 7, 2022Microbiology

Antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5

Q. Wang, Y. Guo, S. Iketani, Z. Li, H. Mohri, M. Wang, J. Yu, A. D. Bowen, J. Y. Chan, J. G. Shah, N. Nguyen, Z. Chen, K. Meyers, M. T. Yin, M. E. Sobieszczyk, , D. Ho

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

bioRxiv · May 26, 2022Microbiology