Author

S. P. Maher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:plant (other)· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Vantaux· 5 shared B. Witkowski· 4 shared D. E. Kyle· 4 shared A. A. Ruberto· 2 shared C. A. Cooper· 2 shared J. Peneau· 2 shared A. Botnar· 1 shared A. Harupa-Chung· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersMicrobiology

A. Vantaux

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

S. P. Maher, M. A. Bakowski, A. Vantaux, E. L. Flannery, C. Andolina, M. Gupta, Y. Antonova-Koch, M. Argomaniz, C.-M. Monica, C. Brice, A. T. Chao, A. K. Chatterjee, W. T. Cheng, E. Chuenchob, C. A. Cooper, , McNama

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

bioRxiv · Jan 31, 2023 · PreprintCell Biology

Liver stage fate determination in Plasmodium vivax parasites: characterization of schizont growth and hypnozoite fating from patient isolates

A. Vantaux, J. Peneau, C. A. Cooper, D. E. Kyle, B. Witkowski, S. P. Maher

This study investigates how P. vivax patient isolates and hepatocyte donor lots influence hypnozoite formation and schizont growth in liver stage cultures.

bioRxiv · Jun 16, 2022Microbiology

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

A. A. Ruberto, S. P. Maher, A. Vantaux, C. J. Joyner, C. Bourke, B. Balan, A. Jex, I. Mueller, B. Witkowski, D. E. Kyle

This study uses single-cell RNA sequencing to analyze P. vivax-infected hepatocytes, identifying transcriptomic differences between schizonts and hypnozoites and potential therapeutic targets.

bioRxiv · Feb 1, 2022Microbiology

Alkyne modified purines for assessing activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp.

A. Botnar, G. Lawrence, S. P. Maher, A. Vantaux, B. Witkowski, J. C. Shiau, E. F. Merino, D. De Vore, C. Yang, C. Murray, M. B. Cassera, J. W. Leahy, D. E. Kyle

This study develops alkyne-modified purines as a DNA synthesis marker to distinguish replicating and non-replicating Plasmodium stages, aiding in understanding dormancy mechanisms.

bioRxiv · Oct 12, 2021 · PreprintMicrobiology

Spatial spread of white-nose syndrome in North America, 2006-2018

A. M. Kramer, A. Mercier, S. P. Maher, Y. Kumi-Ansu, S. Bowden, J. M. Drake

The paper analyzes the spatial spread of white-nose syndrome in North America from 2006-2018, finding changing factors influencing its spread over time.

bioRxiv · Jan 28, 2021 · PreprintEcology

The tubovesicular network in Plasmodium vivax liver-stage hypnozoites and schizonts associates with host aquaporin 3

K. Sylvester, S. P. Maher, D. Posfai, M. K. Tran, M. C. Crawford, A. Vantaux, B. Witkowski, D. E. Kyle, E. R. Derbyshire

This study uses high-resolution microscopy to show AQP3 associates with the tubovesicular network in P. vivax hypnozoites and schizonts, revealing dynamic host-parasite interactions during liver-stage infection.

bioRxiv · Dec 9, 2020 · PreprintMicrobiology