Author

C. J. Joyner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Tipton· 2 shared F. E.-H. Lee· 2 shared G. Gibson· 2 shared I. Sanz· 2 shared J. Andrews· 2 shared M. Duan· 2 shared S. Lonial· 2 shared A. A. Ruberto· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

C. Tipton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in P. falciparum Malaria.

Z. M. Chahine, S. Abel, T. Hollin, J. H. Chung, G. L. Barnes, M. E. Daub, I. Renard, J. Y. Choi, P. Vydyam, A. Chattopadhyay Pal, M. Argomaniz, C. Banks, J. kirkwood, A. Saraf, I. Camino Diaz, , K. G. Le Roch

This paper identifies MED6-189, a potent antimalarial compound that disrupts apicoplast function and vesicular trafficking in P. falciparum, showing efficacy against drug-resistant strains and demonstrating a unique mechanism of action.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

M. Duan, D. C. Nguyen, C. J. Joyner, C. Saney, C. Tipton, J. Andrews, S. Lonial, C. Kim, I. Hentenaar, A. Kosters, E. Ghosn, A. Jackson, S. Knechtle, S. Maruthamuthu, S. Chandran, , F. E.-H. Lee

The study maps human bone marrow plasma cell heterogeneity using single-cell transcriptomics, revealing maturation pathways and molecular features of long-lived plasma cells.

bioRxiv · Jan 18, 2023 · PreprintImmunology

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targets

A. A. Ruberto, S. P. Maher, A. Vantaux, C. J. Joyner, C. Bourke, B. Balan, A. Jex, I. Mueller, B. Witkowski, D. E. Kyle

This study uses single-cell RNA sequencing to analyze P. vivax-infected hepatocytes, identifying transcriptomic differences between schizonts and hypnozoites and potential therapeutic targets.

bioRxiv · Feb 1, 2022Microbiology

Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi

M. S. Peterson, C. J. Joyner, J. A. Brady, J. S. Wood, M. Cabrera-Mora, C. L. Saney, L. L. Fonseca, W. T. Cheng, J. Jang, S. A. Lapp, S. R. Soderberg, M. V. Nural, J. C. Humphrey, A. Hankus, D. Machiah, , M. R. Galinski

This study tracks clinical and physiological changes in kra monkeys infected with P. knowlesi, revealing mechanisms of resilience to malaria.

bioRxiv · Jun 28, 2021Pathology

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation

C. J. Joyner, A. Ley, D. Nguyen, M. Ali, A. Corrado, C. Tipton, C. Scharer, T. Mi, M. C. Woodruff, J. Hom, J. M. Boss, M. Duan, G. Gibson, D. Roberts, J. Andrews, , F. E.-H. Lee

This study shows human blood ASCs undergo transcriptional and epigenetic changes in the BM microniche to become apoptotic-resistant LLPC.

bioRxiv · May 22, 2021 · PreprintImmunology