Disrupting the plastid-hosted iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability
E. A. Renaud, S. Pamukcu, A. Cerutti, L. Berry, C. Lemaire-Vieille, Y. Yamaryo-Botte, C. Y. Botte, S. Besteiro
This study shows that disrupting the SUF iron-sulfur cluster pathway in Toxoplasma gondii severely impairs parasite growth and viability through multiple metabolic and functional defects.
bioRxiv · Mar 18, 2022Microbiology