S. R. Azar

Yellow Fever Emergence: Role of Heterologous Flavivirus Immunity in Preventing Urban Transmission

The paper shows that prior immunity to dengue and Zika viruses reduces yellow fever viremia, limiting mosquito infection and urban transmission risk.

CD8+ T cell response promotes viral clearance and reduces chances of severe testicular damage in mouse models of long-term Zika virus infection of the testes.

This study shows CD8+ T cells reduce severe testicular damage in mice with long-term Zika virus infection by promoting viral clearance.

Potential of Ilheus virus to emerge

This study develops murine models of Ilheus virus infection and shows Aedes mosquitoes are highly susceptible, suggesting ILHV is poised for emergence in the neotropics.

Immunologically mediated trade-offs shaping transmission of sylvatic dengue and Zika viruses in native and novel non-human primate hosts

This study investigates immunological trade-offs in non-human primate hosts for dengue and Zika viruses, finding that higher viral replication correlates with increased transmission but reduced antibody response.

Emergence of Zika virus: Direct reversion of mutations and fitness restoration prior to spread to the Americas

This study identifies four mutations in Zika virus that reversed prior mutations, restoring fitness for urban transmission and increasing epidemic risk before the virus spread to the Americas.

Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness

This study investigates resistance to fluoroquinolones in dengue virus serotype 4 and finds that resistance mutations affect viral fitness and binding/entry mechanisms.

Old drugs with new tricks: Efficacy of fluoroquinolones to suppress replication of flaviviruses

This study shows fluoroquinolones like enoxacin inhibit flavivirus replication in human cells and reduce ZIKV titer in mouse testes.