S. R. Hadrup

Identification and characterization of neoantigen-reactive CD8+ T cells following checkpoint blockade therapy in a pan-cancer setting

The paper detects neoantigen-reactive CD8+ T cells in tumor biopsies and peripheral blood post-checkpoint blockade therapy and identifies peptide hydrophobicity and treatment-induced phenotypes as factors influencing their response.

mRNA-delivered consensus allergens induce a neutralizing IgG response against food and pollen allergens

This study shows that mRNA-delivered consensus allergens induce neutralizing IgG responses against multiple food and pollen allergens, offering a safer and broader allergy immunotherapy approach.

Simultaneous analysis of pMHC binding and reactivity unveils virus-specific CD8 T cell immunity to a concise epitope set

The paper identifies a concise set of 137 virus-specific CD8 T cell epitopes recognized by human T cells, with 84% showing prevalent reactivity and associations with effector and memory phenotypes.

Interferon-α promotes neo-antigen formation andpreferential HLA-B-restricted antigen presentation in pancreatic β-cells

This study shows that IFN-α increases HLA-B-restricted antigen presentation in pancreatic β-cells, potentially influencing T1D pathogenesis.

ATRAP - Accurate T cell Receptor Antigen Pairing through data-driven filtering of sequencing information from single-cells

ATRAP filters sequencing artifacts to accurately pair T cell receptors with their cognate peptide-MHC ligands from single-cell data, identifying 1494 high-confidence pairs across 16 donors.

Three-doses of BNT162b2 COVID-19 mRNA vaccine establishes long-lasting CD8+ T cell immunity in CLL and MDS patients

This study evaluates the BNT162b2 vaccine's ability to induce and maintain CD8+ T cell immunity in CLL and MDS patients, showing increased T cell frequencies after booster doses.

SARS-CoV-2 genome-wide mapping of CD8 T cell recognition reveals strong immunodominance and substantial CD8 T cell activation in COVID-19 patients

This study maps SARS-CoV-2 epitopes recognized by CD8 T cells in COVID-19 patients, showing strong immunodominance and activation, with severe cases having the largest T cell populations.