Author

T. P. Jenkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Pharmacology & Toxicology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1 Assay:proteomics· 1

Frequent Co-Authors

A. H. Laustsen· 3 shared J. M. Gutierrez· 3 shared C. A. Dawson· 2 shared E. Crittenden· 2 shared K. E. Bartlett· 2 shared N. R. Casewell· 2 shared S. R. Hall· 2 shared W. M. Laprade· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBioengineering

A. H. Laustsen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

mRNA-delivered consensus allergens induce a neutralizing IgG response against food and pollen allergens

M. Moiniche, K. H. Johansen, J. Parron-Ballesteros, J. K. Corneliussen, H. H. Eriksen, J. V. Kringelum, S. R. Hadrup, O. Luengo, V. Cardona, J. Bartra, M. Pascal, J. Turnay, M. Villalba, R. Munter, T. P. Jenkins, , E. Rivera-de-Torre

This study shows that mRNA-delivered consensus allergens induce neutralizing IgG responses against multiple food and pollen allergens, offering a safer and broader allergy immunotherapy approach.

bioRxiv · Feb 26, 2024Bioengineering

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

K. E. Bartlett, S. R. Hall, S. A. Rasmussen, E. Crittenden, C. A. Dawson, L.-O. Albulescu, W. M. Laprade, R. A. Harrison, A. J. Saviola, C. M. Modahl, T. P. Jenkins, M. C. Wilkinson, J. M. Gutierrez, N. R. Casewell

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

bioRxiv · Jul 20, 2023Pharmacology & Toxicology

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

W. M. Laprade, K. E. Bartlett, C. R. Christensen, T. D. Kazandjian, R. N. Patel, E. Crittenden, C. A. Dawson, M. Mansourvar, D. S. Wolff, T. J. Fryer, A. H. Laustsen, N. R. Casewell, J. M. Gutierrez, S. R. Hall, T. P. Jenkins

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

bioRxiv · May 21, 2023Pharmacology & Toxicology

Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms

L. Ledsgaard, J. Wade, K. Boddum, I. Oganesyan, J. Harrison, T. P. Jenkins, P. Villar, R. A. Leah, R. Zenobi, J. McCafferty, B. Lomonte, J. M. Gutierrez, A. H. Laustsen, A. Karatt-Vellatt

This paper describes the discovery of a broadly-neutralizing human antibody effective against multiple snake venoms, demonstrating its therapeutic potential in mice.

bioRxiv · Jun 17, 2022 · PreprintBioengineering

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

M. A. Duque-Correa, N. A. Karp, C. McCarthy, S. Forman, D. Goulding, G. Sankaranarayanan, T. P. Jenkins, A. J. Reid, H. P. Browne, E. L. Cambridge, C. Ballesteros Reviriego, W. Müller, C. Cantacessi, G. Dougan, R. K. Grencis, , The 3i consortium

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.

bioRxiv · Aug 8, 2018Immunology