Author

M. Jarvis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Cancer Biology· 2 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Organism:human· 2 Organism:non-human primate· 2 Organism:rat· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

K. Rosenke· 6 shared A. Okumura· 5 shared F. Feldmann· 5 shared H. Feldmann· 5 shared K. Meade-White· 4 shared C. Shaia· 3 shared G. Saturday· 3 shared J. Lovaglio· 3 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

K. Rosenke

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

K. Rosenke, M. Lewis, F. Feldmann, E. Bohrnsen, B. Schwarz, A. Okumura, W. F. Bohler, J. Callison, C. Shaia, C. Bosio, J. Lovaglio, G. Saturday, M. Jarvis, H. Feldmann

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

bioRxiv · Sep 3, 2022Microbiology

Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer

M. A. Carpenter, N. A. Temiz, M. Ibrahim, M. Jarvis, M. Brown, P. Argyris, W. Brown, D. Yee, R. S. Harris

This study quantifies the mutagenic activities of APOBEC3A and APOBEC3B in a human cell line and compares their mutation signatures to breast cancer genomes, showing both enzymes contribute to the mutation landscape.

bioRxiv · Apr 26, 2022Cancer Biology

Molnupiravir (MK-4482) is efficacious against Omicron and other SARS-CoV-2 variants in the Syrian hamster COVID-19 model

K. Rosenke, A. Okumura, M. C. Lewis, F. Feldmann, K. Meade-White, W. F. Bohler, A. Griffin, R. Rosenke, C. Shaia, M. Jarvis, H. Feldmann

MK-4482 inhibits replication of multiple SARS-CoV-2 variants of concern, including Omicron, in the Syrian hamster model.

bioRxiv · Feb 22, 2022 · PreprintMicrobiology

UK B.1.1.7 variant exhibits increased respiratory replication and shedding in nonhuman primates

K. Rosenke, F. Feldmann, A. Okumura, F. Hansen, T.-L. Tang-Huau, K. Meade-White, B. Kaza, B. J. Smith, P. W. Hanley, J. Lovaglio, M. Jarvis, C. Shaia, H. Feldmann

This study compares the respiratory replication and shedding of SARS-CoV-2 D614G and B.1.1.7 variants in African green monkeys, finding increased respiratory replication for B.1.1.7 but no disease enhancement.

bioRxiv · Jun 11, 2021Microbiology

Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection

K. Rosenke, K. Meade-White, M. C. Letko, C. Clancy, F. Hansens, Y. Liu, A. Okumura, T.-L. Tang-Huau, R. Li, G. Saturday, F. Feldmann, D. Scott, Z. Wang, V. Munster, M. Jarvis, H. Feldmann

The paper shows Syrian hamsters are highly susceptible to SARS-CoV-2, making them a suitable model for developing countermeasures against COVID-19.

bioRxiv · Sep 25, 2020Microbiology

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

K. Rosenke, M. Jarvis, F. Feldmann, B. Schwarz, A. Okumura, J. Lovaglio, G. Saturday, P. Hanley, K. Meade-White, B. Williamson, F. Hansen, L. Perez-Perez, S. Leventhal, T.-L. Tang-Huau, M. Nason, , H. Feldmann

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

bioRxiv · Jun 10, 2020 · PreprintPharmacology & Toxicology

APOBEC3A Catalyzes Mutation and Drives Carcinogenesis In Vivo

E. Law, R. Levin-Klein, M. Jarvis, H. Kim, P. Argyris, M. Carpenter, G. Starrett, L. Larson, M. Burns, R. Vogel, S. Stavrou, A. Aguilera, S. Wagner, D. Largaespada, T. Starr, , R. Harris

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

bioRxiv · Dec 27, 2019Cancer Biology

Bayesian estimation of Lassa virus epidemiological parameters: implications for spillover prevention using wildlife vaccination

S. L. Nuismer, C. H. Remien, A. Basinski, T. Varrelman, N. Layman, K. Rosenke, B. Bird, M. Jarvis, P. Barry, E. Fichet-Calvet

This paper develops a Bayesian method to estimate Lassa virus epidemiological parameters and evaluates rodent vaccination efficacy using simulated and real data from Guinea.

bioRxiv · Nov 13, 2019Ecology

Polyomavirus T-Antigen Induces APOBEC3B Expression using a LXCXE-Dependent and TP53-Independent Mechanism

G. Starrett, A. Serebrenik, P. Roelofs, B. Verhalen, J. McCann, M. Jarvis, T. Stewart, E. Law, A. Krupp, M. Jiang, J. Martens, P. Span, E. Cahir-McFarland, R. Harris

This paper shows polyomavirus T-antigen induces APOBEC3B expression via the LXCXE motif without requiring TP53 inhibition, linking RB/E2F axis activation to APOBEC3B upregulation in virus-infected cells.

bioRxiv · May 2, 2018Microbiology