Myocardial damage induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.
E. Forte, M. Panahi, F. S. Ng, J. J. Boyle, J. Branca, O. Bedard, M. G. Hasham, L. Benson, S. E. Harding, N. Rosenthal, S. Sattler
This study shows that a single high dose of isoproterenol in mice causes myocardial damage and a persistent adaptive immune response against the heart, making it a suitable model for studying anti-heart autoimmunity.
bioRxiv · Feb 27, 2020Immunology