S. Sharma

This study identifies novel inhibitors that disrupt the mTORC2 complex and induce apoptosis in chronic lymphocytic leukemia cells more effectively than existing treatments.

This study identifies KMT2D as a tumor suppressor in melanoma, showing its loss leads to metabolic reprogramming toward glycolysis and dependence on IGF signaling, suggesting therapeutic targeting of these pathways.

This study compares viral characteristics in two HIV-1C infected monozygotic twins with differing elite neutralizing antibody profiles, identifying viral mutations associated with neutralization resistance and susceptibility.

The paper identifies a negative feedback loop between membrane tension and the CLIC/GEEC pathway mediated by vinculin and GBF1.

The paper develops two in vitro assays to screen inhibitors of ETS transcription factors and finds that lower affinity DNA-binding sequences enhance compound inhibition.

This study identifies and characterizes NF-Y transcription factors involved in rice endosperm development, showing sub-functionalization and interaction patterns among subunits.

The paper shows that the glutathione and thioredoxin systems in P. falciparum can functionally complement each other, compensating for the absence of key antioxidant proteins in certain compartments.