S. T. Magness

An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal stem cells

The paper develops two fluorescent reporter systems and imaging platforms to analyze cell cycle phases in living primary human intestinal stem cells.

Design of 8-mer Peptides that Block Clostridioides difficile Toxin A in Intestinal Cells

The paper designs 8-mer peptides that block Clostridioides difficile toxin A in intestinal cells using a combination of computational and experimental methods.

Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period

This study shows that the developing enteric glial cell network is essential for intestinal epithelial barrier repair after ischemic injury in neonates.

SOX9 elongates cell cycle phases and biases fate decisions in human intestinal stem cells

This study shows SOX9 in human intestinal stem cells slows proliferation, extends G1 phase, and biases differentiation toward specific cell fates.

A Leaky Human Colon Model Reveals Uncoupled Apical/Basal Cytotoxicity in Early Clostridioides difficile Toxin Exposure

This study develops a human colon model to assess how C. difficile toxins affect epithelial cells from different sides, finding that basal exposure causes more severe toxicity.

Transcriptomics informs design of a planar human enterocyte culture system that reveals metformin enhances fatty acid export

The paper develops a human enterocyte culture system to study lipid handling and finds metformin enhances fatty acid export by promoting fatty acid oxidation.

A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics

The paper uses single-cell transcriptomics to analyze healthy adult human small intestine and colon epithelium, identifying lineage markers, regional differences, and functional variations across anatomical regions.

Sox4 drives Atoh1-independent intestinal secretory differentiation toward tuft and enteroendocrine fates

This study shows Sox4 drives intestinal secretory differentiation toward tuft and enteroendocrine fates independently of Atoh1.

Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine

This study shows that Cftr loss increases intestinal stem cell proliferation and Wnt/β-catenin signaling by altering intracellular pH and enhancing Dvl2 membrane association in CF mice.