A. Zheng

Evolutionary conserved cis-trans regulation machinery for diterpenoid phytoalexin production in Poaceae

The paper investigates the regulatory mechanisms of diterpenoid phytoalexin production in wild rice, identifying DPF and N-boxes as key cis-trans regulators conserved across species.

The first discovery of SFTSV in the Centre of Metropolitan Beijing, China

This study identifies SFTSV circulation in central Beijing by surveying ticks and hedgehogs, revealing high seroprevalence and RNA prevalence in urban areas.

An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal stem cells

The paper develops two fluorescent reporter systems and imaging platforms to analyze cell cycle phases in living primary human intestinal stem cells.

SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia

This study shows that SARS-CoV-2 N protein reduces Dicer, XPO5, SRSF3, and hnRNPA3, leading to pneumonia, and that inhibitors can reverse this effect.

Efficient inhibition of fusion inhibitor HY3000 peptide to SARS-CoV-2 emerging EG.5, EG.5.1 and BA.2.86 variants

This study evaluates the inhibitory activity of the HY3000 peptide against emerging SARS-CoV-2 variants EG.5, EG.5.1, and BA.2.86, finding it retains potent antiviral effects.

Natural Circulation of Tick-borne Severe Fever with Thrombocytopenia Syndrome Virus in the City Ecosystem, China

The paper reports the natural circulation of SFTSV between Asian long-horned ticks and hedgehogs in Beijing, highlighting their role in maintaining the virus in the urban ecosystem.

Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

This study identifies the transsulfuration pathway as a targetable metabolic driver of glioblastoma invasion through multi-omic analyses of engineered biomaterials and patient biopsies.

SOX9 elongates cell cycle phases and biases fate decisions in human intestinal stem cells

This study shows SOX9 in human intestinal stem cells slows proliferation, extends G1 phase, and biases differentiation toward specific cell fates.

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation

This study shows that lncRNA Malat1 restricts Th17 cell IL-17A production by regulating a bivalent super-enhancer, thereby controlling intestinal inflammation resolution.

Hedgehogs are the major amplifying hosts of severe fever with thrombocytopenia syndrome virus

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

Replication is the key barrier during the dual-host adaption of mosquito-borne flaviviruses

This study identifies key molecular factors determining mosquito-borne flavivirus host tropism by comparing insect-specific and dual-host flaviviruses.

Reduced sera neutralization to Omicron SARS-CoV-2 by bothinactivated and protein subunit vaccines and the convalescents

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

Neutralization of recombinant RBD-subunit vaccine ZF2001-elicited antisera to SARS-CoV-2 variants including Delta

This study evaluates the neutralizing activity of ZF2001 vaccine-elicited antisera against SARS-CoV-2 variants, finding that E484K/Q mutations reduce neutralization and that extended intervals between doses improve variant resilience.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

HDLs extract lipophilic drugs from cells

This study shows HDLs extract lipophilic drugs from cells, reducing toxicity but potentially diminishing therapeutic efficacy of drugs like glibenclamide.

ADAR2 deaminase activity promotes Th17 effector function and protects against intestine inflammation

This study shows ADAR2 promotes Th17 effector function by editing Malt1, leading to increased IL-17A and protection against intestinal inflammation.

Dynamic Palmitoylation Events Following T-Cell Receptor Signaling

The paper identifies dynamic palmitoylation events in T-cells following TCR signaling, showing DHHC18 palmitoylates VAMP7 at Cys183, affecting its Golgi retention.