K. Kondo

Systematic Discovery of Phage Genes that Inactivate Bacterial Immune Systems

This study identifies phage genes that inactivate bacterial immune systems by testing gene deletions in a phage library against bacterial defense systems.

In vitro activity of cefiderocol against carbapenemase-producing and meropenem-nonsusceptible gram-negative bacteria collected in the Japan Antimicrobial Resistant Bacterial Surveillance (JARBS-GNR)

This study evaluates the in vitro activity of cefiderocol against carbapenemase-producing and meropenem-nonsusceptible gram-negative bacteria from Japan, showing high susceptibility rates compared to other antibiotics.

Viruses encode tRNA and anti-retron to evade bacterial immunity

This study identifies two viral strategies to evade bacterial retrons: supplying tRNATyr to counteract retron 78 and using Rad to degrade retron noncoding RNA precursors.

Selective bacteriophages reduce the emergence of resistant bacteria in the bacteriophage-antibiotic combination therapy

This study shows that selecting specific bacteriophages in combination with antibiotics can reduce the emergence of resistant bacteria, using Escherichia coli O157:H7 as a model.

Isolation and characterization of bacteriophages against IMP-6-producing Klebsiella pneumoniae isolated from clinical settings in Japan

The paper isolates and characterizes 29 bacteriophages against IMP-6-producing Klebsiella pneumoniae from Japan, showing broad host ranges and demonstrating the effectiveness of a phage cocktail in delaying phage-resistant bacteria emergence.

Delayed SARS-CoV-2 Spread and Olfactory Cell Lineage Impairment in Close-Contact Infection Syrian Hamster Models

This study investigates SARS-CoV-2 transmission via close contact in Syrian hamsters and shows delayed olfactory cell lineage damage compared to direct infection.

SARS-CoV-2 causes brain inflammation via impaired neuro-immune interactions

This study develops a mouse model of SARS-CoV-2-induced brain inflammation and identifies impaired cholinergic anti-inflammatory pathway as a mechanism, suggesting donepezil as a potential treatment.

Prophage elements function as reservoir for antibiotic resistance and virulence genes in nosocomial pathogens

This study analyzes prophage elements in seven pathogens to show they carry a wide range of antibiotic resistance and virulence genes, with AMR genes being more conserved across species than VF genes.

Expression of Ace2, Tmprss2, and Furin in mouse ear tissue

This study examines the expression of Ace2, Tmprss2, and Furin in mouse ear tissues, finding co-expression in the middle ear that suggests susceptibility to SARS-CoV-2.

Understanding olfactory dysfunction in COVID-19: Expression of ACE2, TMPRSS2 and Furin in the nose and olfactory bulb in human and mice

The paper examines ACE2, TMPRSS2, and Furin expression in nasal and olfactory tissues of humans and mice to understand the mechanisms of COVID-19 related anosmia.

Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats

This study examines ACE2 and TMPRSS2 protein expression in rat aerodigestive tracts to understand SARS-CoV-2 infection mechanisms and correlate with COVID-19 symptoms.

Handling and Packaging of Medical Bags at the Acute Disaster Site Under High Temperature Conditions

This study evaluates how medical bags retain temperature in high heat disaster environments, finding that closed and semi-opened bags with insulation and coolant maintain lower internal temperatures than opened bags.

Physiological determinants of the increase in oxygen consumption during exercise in individuals with stroke

This study identifies physiological determinants of oxygen consumption increase during exercise in stroke patients using multivariate analysis of respiratory, cardiac, and skeletal muscle parameters.

Life in coastal pebble sediment: Unique interstitial organism community and selective feeding on meiobenthos by interstitial fishes (Luciogobius: Gobiidae)

This study examines the diet and interstitial organism communities of two Luciogobius goby species, revealing their exclusive reliance on meiobenthos and selective feeding preferences.