Increased RAMP3 expression enhances GLP-1 mediated Glucose Stimulated Insulin Secretion in a Manner Dependent on Ca2+ Mobilisation
Abigail Pearce, Poonam Kumari, Claudia M. Sisk, Matthew Harris, Ho Yan Yeung, Sabrina Winfield, Kathleen M. Caron, Graham Ladds
RAMP3 complexes with GLP-1R at the plasma membrane, shifts signalling toward Ca2+ mobilisation, and enhances insulin secretion in INS-1 832/3 cells; Ramp3 loss blunts GLP-1 responses in mice.
Journal of Biological Chemistry · Aug 19, 2025Peer-reviewedPharmacology & Toxicology✦ In-depth digest