Author

Melpomeni Toitou

University of ZurichORCID 0000-0002-4402-304XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Caroline OspeltiD· 3 shared Katerina ApostolopoulouiD· 3 shared Raphael MicheroliiD· 3 shared Alexandra A. KhmelevskayaiD· 2 shared Celina GeißiD· 2 shared Chantal PauliiD· 2 shared Ege EzeniD· 2 shared Katharina Zachariassen· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Caroline OspeltORCID

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Author profile →

3 papers

Recent·Most cited

Synovitis in systemic sclerosis is an interferon-driven stromal condition distinct from rheumatoid arthritis

Celina Geiß, Camino Calvo-Cebrián, Miranda Houtman, Ege Ezen, Katerina Apostolopoulou, Cristian Iperi, Melpomeni Toitou, Alexandra A. Khmelevskaya, Marija Lugar, Anne Cauvet, Yannis Djeffal, Mojca Frank‐Bertoncelj, Sam G. Edalat, Thomas Rauer, Katharina Zachariassen, , Muriel Elhaï

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

bioRxiv · Jul 2, 2026 · PreprintImmunology

Human Fibroblast-Myeloid cell tissue atlas across lung, synovium, skin and heart

Lucy MacDonald, Katerina Apostolopoulou, Olympia M Hardy, Melpomeni Toitou, Gabriela Kania, Przemysław Błyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt

The paper analyzes scRNAseq data from multiple tissues to identify shared and tissue-specific myeloid and stromal cell populations in health and disease.

Arthritis & Rheumatology · Jun 1, 2026Peer-reviewedCell Biology

Disease-specific fibroblast-myeloid interactions in rheumatoid arthritis synovium

Alexandra A. Khmelevskaya, Katerina Apostolopoulou, Camino Calvo Cebrian, Ege Ezen, Melpomeni Toitou, Phatthamon Laphanuwat, Masoumeh Mirrahimi, Celina Geiß, Marija Lugar, Asimina Kakale, Silja Malkewitz, Andrea Laimbacher, Dimitris Konstantopoulos, Vagelis E. Rinotas, Marietta Armaka, , Caroline Ospelt

This study identifies disease-specific fibroblast-myeloid interactions in RA synovium, showing SPP1 signaling and fibroblast-myeloid-dendritic interactions drive RA inflammation by linking innate immunity to autoimmunity.

bioRxiv · Nov 17, 2025 · PreprintImmunology