Modeling CISH-KO TIL therapy: T-cell persistence and endogenous competition determine response in gastrointestinal cancer
Xuanming Zhang, Sarah Anderson, Kamran Kaveh, Matthew J Johnson, David J. Odde, Beau R. Webber, Branden S. Moriarity, Emil Lou, Kevin Leder, Jasmine Foo
This study models CISH-KO TIL therapy in gastrointestinal cancer, finding that T-cell persistence and endogenous competition are key determinants of treatment response.
bioRxiv · Jun 11, 2026 · PreprintCancer Biology