Saskia C. A. de Jager

This paper introduces NEO-AAV, an engineered AAV platform that enhances T cell transduction and CAR-T cell generation by enveloping AAV in extracellular vesicles, improving immune resistance and transduction efficiency.

The paper develops a cardiac spheroid model with monocytes to better mimic heart failure responses, showing improved functional and transcriptional changes compared to models without immune cells.

This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.

This study investigates how hypoxia and TNF-alpha affect extracellular vesicle release from hiPSC-CMs under stress conditions, identifying nSmase2 and mTOR signaling pathways involved.