Author

Say-Tar Goh

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Barbara J. WoldiD· 3 shared Andrew A. HardiganiD· 2 shared E. Christopher Partridge· 2 shared R MyersiD· 2 shared Ryne C. RamakeriD· 2 shared Alex BurriD· 1 shared Ali MortazaviiD· 1 shared Allen W CheniD· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersGenomics

Barbara J. WoldORCID

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Author profile →

4 papers

Recent·Most cited

3D genome organization around nuclear speckles drives mRNA splicing efficiency

Prashant Bhat, Amy Y. Chow, Benjamin L. Emert, Olivia Ettlin, Sofia A. Quinodoz, Mackenzie M. Strehle, Yodai Takei, Alex Burr, Isabel Nadine Goronzy, Allen W Chen, Wesley Huang, Jose Lorenzo M. Ferrer, Elizabeth Soehalim, Say-Tar Goh, Tara Chari, , Mitchell Guttman

The paper shows that gene proximity to nuclear speckles increases spliceosome binding and co-transcriptional splicing efficiency, highlighting the role of 3D genome organization in mRNA splicing.

Nature · May 8, 2024Peer-reviewedMolecular Biology

The changing mouse embryo transcriptome at whole tissue and single-cell resolution

Peng He, Brian A. Williams, Diane E. Trout, Georgi K. Marinov, Henry Amrhein, Libera Berghella, Say-Tar Goh, Ingrid Plajzer-Frick, Veena Afzal, Len A. Pennacchio, Diane E. Dickel, Axel Visel, Bing Ren, Ross C. Hardison, Yu Zhang, Barbara J. Wold

The paper quantifies the mouse embryo transcriptome from E10.5 to birth using whole-tissue and single-cell RNA-seq, identifying key gene expression patterns and cell types.

Nature · Jul 29, 2020Peer-reviewedDevelopmental Biology

Dissecting the regulatory activity and sequence content of loci with exceptional numbers of transcription factor associations

Ryne C. Ramaker, Andrew A. Hardigan, Say-Tar Goh, E. Christopher Partridge, Barbara J. Wold, Sara J. Cooper, R Myers

The paper identifies and characterizes HOT loci with high DAP associations, finds driver motifs, and shows their regulatory importance through mutagenesis.

Genome Research · Jul 1, 2020Peer-reviewedGenomics

Occupancy patterns of 208 DNA-associated proteins in a single human cell type

E. Christopher Partridge, Surya B. Chhetri, Jeremy W. Prokop, Ryne C. Ramaker, Camden S. Jansen, Say-Tar Goh, Mark Mackiewicz, Kimberly M. Newberry, Laurel A. Brandsmeier, Sarah Kristen Meadows, C. Luke Messer, Andrew A. Hardigan, Emma C. Dean, Shan Jiang, Daniel Savic, , Eric M. Mendenhall

The paper presents ChIP-seq data for 208 DNA-associated proteins in HepG2 cells, revealing occupancy patterns and DNA motifs, and distinguishing promoters from enhancers.

bioRxiv · Nov 7, 2018 · PreprintGenomics