Sedona Lockhart

The anterior insular cortex mediates higher-order threat learning and memory

This study identifies the role of anterior insular cortex neurons in higher-order threat learning and memory, showing they are essential for temporally separated or diffuse threat contexts but constrain fear expression during retrieval.

The anterior insular cortex associates temporally discontiguous stimuli during threat learning

This study identifies the role of the anterior insular cortex in associating temporally discontiguous stimuli during threat learning in mice.

Prolonged HPA axis dysregulation in postpartum depression associated with adverse lifeexperiences during development: a cross-species translational study for a novel therapeutic approach

This study shows that adolescent stress leads to prolonged HPA axis dysregulation and postpartum depression, with a GR antagonist showing therapeutic potential in mice and humans.