Minae Niwa

FcγR- and CD9-dependent synapse engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage

The paper shows that thalamic microglia engulfing synapses, driven by CD9 and FcγRIII signals, cause cognitive impairment after cortical injury.

Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers

This study shows that adolescent social isolation in mice impairs maternal care and leads to social deficits in offspring, which can be mitigated by social support from experienced mothers.

Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in mice

The paper shows that EV miRNAs from WT mice improve sociability in immunodeficient mice by modulating synaptic function and immune-neuron communication.

Adolescent stress impairs postpartum social behavior via anterior insula-prelimbic pathway

This study identifies a cortico-cortical pathway linking adolescent stress to postpartum social behavior deficits in mice.

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

This study identifies the miR-124-AMPAR pathway as a common mediator linking polygenic risks to shared behavioral changes in schizophrenia and bipolar disorder.

Nuclear GAPDH in cortical microglia mediates stress-induced cognitive inflexibility

This study identifies the nuclear GAPDH cascade in microglia as a mediator of stress-induced cognitive inflexibility and shows that targeting it can normalize cognitive deficits.

Prolonged HPA axis dysregulation in postpartum depression associated with adverse lifeexperiences during development: a cross-species translational study for a novel therapeutic approach

This study shows that adolescent stress leads to prolonged HPA axis dysregulation and postpartum depression, with a GR antagonist showing therapeutic potential in mice and humans.

Increased amphetamine-induced hyperactivity in translin (Tsn) KO mice is driven by elevated adiposity

This study shows that Tsn knockout mice exhibit increased amphetamine-induced hyperactivity due to elevated adiposity, which raises brain amphetamine levels.