Varun S. Sudunagunta

Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome

This study investigates how Stag2-dependent chromatin remodeling influences Gata1's function in erythropoiesis, revealing its role in lineage-specific gene regulation and dyserythropoiesis in MDS.

Altered chromatin accessibility mediated by somatic cohesin mutations amplifies FLI1-Menin output to promote leukemogenesis

This study shows that cohesin mutations alter chromatin accessibility, enhancing FLI1-Menin interaction and promoting leukemogenesis through therapeutic vulnerabilities.

Polyamines regulate cell fate by altering the activity of histone-modifying enzymes

This study shows that polyamines regulate cell fate by altering chromatin structure through interactions with histone-modifying enzymes.

RUNX1 haploinsufficiency causes a marked deficiency of megakaryocyte-biased hematopoietic progenitor cells: Mechanistic studies and drug correction

This study shows that RUNX1 haploinsufficiency reduces megakaryocyte-biased hematopoietic progenitor cells and identifies drug targets to correct this defect.